The Effects Of The DDS-1 Strain Of Lactobacillus On Symptomatic Relief For Lactose Intolerance

Michael N. Pakdaman, MD, Jay K. Udani, Jhanna Pamela Molina and Michael Shahani

The aim of this randomized, double-blind, placebo-controlled, crossover clinical trial was to evaluate the effect of the DDS-1 strain of L. acidophilus , as manufactured by Nebraska Cultures, on relieving discomfort related to lactose intolerance.

Comparison between the active group and the placebo group demonstrated statistically significant reductions in abdominal symptom scores for diarrhea, abdominal cramping, vomiting and overall symptoms. This may be indicative of an increased ability to handle lactose load, which may allow individuals to consume more lactose in their diet.  No adverse events were reported.

Published May 20, 2016  |  Nutrition Journal 15:56


Comparison of the Colonization Ability of Autochthonous and Allochthonous Strains of Lactobacilli in the Human Gastrointestinal Tract

Steven A. Frese, Robert W. Hutkins, Jens Walter

In order to receive potential health benefits from probiotic organisms, they must survive passage through the gastrointestinal tract. In a recent study published in the September 2012 issue of Advances in Microbiology, researchers at the University of Nebraska studied the ability of three Lactobacillus species to not only survive, but persist in the human gastrointestinal tract. These species included two strains recognized as being “autochthonous,” or native to the human gastrointestinal tract (but not probiotic in nature) and the probiotic strain L. acidophilus DDS-1. The study was conducted over three individual eight-week periods. After a period of daily consumption of each organism, researchers measured bacterial populations of each organism over time thereafter.

Key Points include:

  • L. acidophilus DDS-1 survives passage through the gastrointestinal tract and can be recovered alive from subjects consuming the organism.
  • Even strains which have an ancient history with humans (Lactobacillus reuteri PTA6475) and a strain that successfully colonized a healthy adult human (Lactobacillus mucosae FSL-04) do not persist longer than L. acidophilus DDS-1 when subjects end consumption of these organisms.
  • All three strains were eliminated from the gastrointestinal tract eight days after subjects stopped consuming the products.
  • The best way to maintain high numbers of Lactobacillus spp. in the gastrointestinal tracts is through routine consumption of the organism.

Published 2012  |  Advances in Microbiology 2(3): 399-409